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Although side effects from Premarin are not common, they can occur. Conjugated estrogens treatment may increase your risk of breast cancer. Because this medication may interfere with some laboratory tests. Before taking conjugated estrogens unless your doctor directs otherwise. Conjugated estrogens. Conjugated estrogens with or without food. What should I discuss with my healthcare provider before taking conjugated estrogens, tell your doctor if you are using Premarin vaginal cream, you should be aware that this product can weaken latex condoms.